Current Research Status of Transcranial Alternating Current Stimulation on Depression-Related Brain Regions

Transcranial alternating current stimulation (tACS) is an emerging non-invasive neuromodulation therapy that has shown considerable potential in the treatment of depressive disorders in recent years. However, which key brain regions mediate its antidepressant effects remains inconclusive. Current research on tACS for depressive disorders has mainly focused on core brain regions such as the dorsolateral prefrontal cortex, medial prefrontal cortex, and hippocampus. Existing evidence suggests that tACS may, through frequency-specific neural oscillation entrainment, induce synaptic plasticity...