The relationship between serum BDNF and Klotho levels and intellectual impairment in children with drug-resistant epilepsy, along with their predictive value.

Objective: To investigate the relationship between serum brain-derived neurotrophic factor (BDNF) and Klotho levels and intellectual impairment in children with drug-resistant epilepsy. Additionally, to analyze the predictive value of these factors in predicting intellectual damage. Methods: A prospective study was conducted. Children with drug-resistant epilepsy admitted to the hospital between October 2020 and October 2024 were selected as the study population. Healthy children who underwent physical examinations during the same period served as the control group. All children in the study population underwent a 12-month follow-up. The Chinese-Wechsler Intelligence Scale for Children was used for assessment…