Mendelian randomization study on the causal relationship between emotional fluctuations, childhood abuse, and irritable bowel syndrome

Objective: This study aims to conduct a two-step, two-sample Mendelian randomization analysis to determine the causal relationship between childhood abuse and irritable bowel syndrome. It also seeks to elucidate the role of emotional fluctuations in this causal relationship, as well as their proportion of influence. Methods: Using publicly available genome-wide association study (GWAS) statistical data, the inverse variance weighted method was employed as the primary analysis technique for conducting Mendelian randomization analysis of the relationship between childhood abuse and irritable bowel syndrome. The analysis was conducted using a two-step approach…