Research on the association between major depressive disorder, metabolic syndrome, and cardiovascular diseases

The purpose of this study is to investigate the relationship between major depressive disorder (MDD) and various common cardiovascular diseases (CVDs). Additionally, we aim to assess the role of metabolic syndrome (MetS) and its components as mediators between MDD and CVDs. Methods: Based on data from large-scale genome-wide association studies (GWAS), we used linkage disequilibrium scoring regression (LDSC) to determine the genetic associations between MDD and angina pectoris, myocardial infarction, coronary artery disease, and heart failure. Furthermore, two-sample Mendelian randomization analysis was employed to further evaluate the relationships between MDD and these CVDs.