Exploratory study on factors related to the worsening of neurological symptoms in patients with Wilson's disease treated with penicillamine: a single-center retrospective analysis

Objective: This study aims to identify the factors that increase the risk of worsening neurological symptoms in patients with Wilson’s disease after initial treatment with penicillamine. Methods: A retrospective analysis was conducted on patients with Wilson’s disease who started treatment with penicillamine. Patients were divided into two groups based on their response to treatment: those with worsening symptoms and those with stable conditions. Clinical signs, cranial MRI results, and medication regimens were collected. Logistic regression analysis was used to identify the risk factors for worsening neurological symptoms. Results: A total of 57 patients with Wilson’s disease who started treatment with penicillamine were included. There were 29 patients in the worsening symptom group and 28 patients in the stable condition group. Logistic regression analysis revealed several factors that were associated with worsening neurological symptoms.