Nuclear factor E2-related factor 2 regulates neuroinflammation following myeloid cell-mediated TBI

Nuclear factor E2-related factor 2 (NRF2) acts as a key regulator of antioxidant and anti-inflammatory responses. It plays a crucial role in regulating the inflammatory responses mediated by myeloid cells after traumatic brain injuries (TBI). NRF2 influences the morphology, polarization state, metabolic reprogramming, and functional effects of myeloid cells, thereby modulating the processes of secondary inflammatory damage and tissue repair. At the molecular level, NRF2 interacts with nuclear factor κB (NF-κB) to facilitate these processes.